Differentiating Crohn’s disease from intestinal tuberculosis

Table 5 Comparison of pathologic findings between Crohn’s disease and intestinal tuberculosis

	Gan et al[27], 2002		Pulimood et al[28], 2005		Kirsch et al[30], 2006		Jin et al[31], 2010		Makharia et al[7], 2010		Yu et al[8], 2012		Ye et al[32], 2015		Jung et al[20], 2016		Overall
Diagnosis	TB	CD	TB	CD	TB	CD	TB	CD	TB	CD	TB	CD	TB	CD	TB	CD	TB	CD
Number of patients	39	30	33	31	18	25	52	26	53	53	53	40	16	52	98	158
Granulomas	54	30							62	53	70	22	81	67	67	54	54-81	22-67
Caseous necrosis	18	0	36	0	22	0	27	0	13	2	13	0			39	0	13-40	0
Confluent granulomas	-	-	42	3	50	0	46	8	-	-	40	3	39	6	-	-	39-60	0-6
5 granulomas/biopsy site	-	-	45	0	44	24	-	-	22	4	20	0	-	-	-	-	40-44	0-24
10 granulomas/biopsy site	-	-	-	-	33	0	-	-	-	-	-	-	-	-	-	-	33	0
Large granulomas	-	-	51	0	67	8	75	19	27	9	43	0	54	11	-	-	27-90	0-27
Microgranuloma	-	-							41	43	-	-			-	-	41	43
Submucosal granulomas	-	-	39	6	44	12	-	-	21	8	-	-	69	54	-	-	21-69	5-54
Ulcers lined by bands of Epithelioid histiocytes	-	-	61	0	61	8	-	-	23	8	-	-	-	-	-	-	23-61	0-8
Disproportionate submucosal Inflammation	-	-	-	-	67	10	-	-	34	17	74	84	-	-	-	-	34-74	5-84
Architectural distortion distant to granulomatous inflammation	-	-	0	62	-	-	-	-	-	-	-	-	81	90	-	-	0-81	62-90
Focal enhanced colitis	-	-	-	-	-	-	-	-	36	68	-	-	-	-	-	-	38	68

All figures are percentages. Last column summarizes all the studies. CD: Crohn’s disease; ITB: Intestinal tuberculosis.