STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats

Figure 1 Changes in interleukin 1β, tumor necrosis factor-α, interleukin 10, heme oxygenase-1, and B-cell lymphoma 2 concentration in gastro-intestinal lesions induced by diclofenac in rats after treatment with omeprazole (20 mg/kg) or STW 5 (5 mL/kg). A: Changes in interleukin 1β concentration in gastric lesions; B: Changes in interleukin 1β concentration in duodenal lesions; C: Changes in tumor necrosis factor-α concentration in gastric lesions; D: Changes in tumor necrosis factor-α concentration in duodenal lesions; E: Changes in interleukin 10 concentration in gastric lesions; F: Changes in interleukin 10 concentration in duodenal lesions; G: Changes in heme oxygenase-1 concentration in gastric lesions; H: Changes in heme oxygenase-1 concentration in duodenal lesions; I: Changes in B-cell lymphoma 2 concentration in gastric lesions; J: Changes in B-cell lymphoma 2 concentration in duodenal lesions. Data are expressed as means ± SD. The significance of the difference between means was tested by ANOVA followed by Tukey Kramer multiple comparisons test. ^aP < 0.05 vs normal; ^bP < 0.01 vs diclofenac-treated group, n = 7. IL-1β: Interleukin 1β; IL-10: Interleukin 10; TNF-α: Tumor necrosis factor-α; HO-1: Heme oxygenase-1; Bcl2: B-cell lymphoma 2.