Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis

Table 4 Overall survival for the entire patient cohort

Parameters	Univariate RR (95%CI)	P value	Multivariate RR (95%CI)	P value
Acute pancreatitis (yes vs no)	2.47 (1.55-3.96)	< 0.001	2.35 (1.45-3.83)	0.001
Chemotherapy, (yes vs no)	0.63 (0.43-0.94)	0.024	0.52 (0.34-0.79)	0.002
Differentiation		0.002		< 0.001
Moderate vs Well	4.65 (1.47-14.72)	0.009	3.07 (0.96-9.84)	0.059
Poor vs Well	7.25 (2.21-23.74)	0.001	6.70 (2.02-22.17)	0.002
T stage, T12 vs T34	0.51 (0.27-0.98)	0.043		0.781
Positive lymph nodes, (yes vs no)	2.32 (1.64-3.29)	< 0.001	2.68 (1.83-3.92)	< 0.001
Perineural invasion, (yes vs no)	1.10 (0.77-1.57)	0.611		0.667
Vascular invasion, (yes vs no)	1.44 (0.86-2.39)	0.164		0.430
Surgical margin, (R1 vs R0)	1.41 (0.69-2.89)	0.346		0.728
TNM stage, (II/III vs I)	2.35 (1.15-4.82)	0.0		0.378
Sex, (male vs female)	1.15 (0.81-1.62)	0.443		0.568
Age (< 65 yr vs ≥ 65 yr )	0.96 (0.69-1.34)	0.803		0.694
tumor site, (distal vs head)	1.52 (1.03-2.24)	0.035	1.90 (1.24-2.90)	0.003

TNM: Tumor node metastasis; RR: Relative risk; CI: Confidence interval.