Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis

Table 3 Cox regression analysis for disease-free survival

Parameters	Univariate RR (95%CI)	P value	Multivariate RR(95%CI)	P value
Acute pancreatitis, (yes vs no)	2.00 (1.19-3.36)	0.009	2.24 (1.31-3.85)	0.003
Chemotherapy, (yes vs no)	0.47 (0.31-0.72)	< 0.001	0.45 (0.29-0.70)	< 0.001
Positive lymph nodes, (yes vs no)	2.02 (1.40-2.91)	< 0.001	2.10 (1.41-3.14)	< 0.001
Vascular invasion, (yes vs no)	1.72(1.00-2.97)	0.051		0.063
Surgical margin, (R1 vs R0)	3.00(1.68-5.35)	< 0.001	2.55 (1.40-4.64)	0.002
Differentiation		0.016		0.019
Moderate vs Well	7.81 (1.92-31.84)	0.004	5.84 (1.42-24.01)	0.014
Poor vs Well	7.13 (1.67-30.38)	0.008	7.84 (1.82-33.74)	0.006
T stage, (T1/T2 vs T3/T4)	0.76 (0.47-1.22)	0.254		0.832
Perineural invasion, (yes vs no)	1.53 (1.07-2.19)	0.020		0.454
TNM stage, (II/III vs I)	2.25 (1.21-4.21)	0.011		0.516
tumor site, (distal vs head)	1.45 (1.00-2.11)	0.051	1.74 (1.15-2.64)	0.009
Age, (< 65 yr vs ≥ 65 yr)	0.82 (0.57-1.16)	0.261		0.404
Sex, (male vs female)	1.07 (0.74-1.55)	0.732		0.951

TNM: Tumor node metastasis; RR: Relative risk; CI: Confidence interval.