Copyright
©The Author(s) 2019.
World J Gastroenterol. Oct 21, 2019; 25(39): 5991-6005
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5991
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5991
Table 4 Univariate analysis of progression-free survival and overall survival in patients with advanced mixed neuroendocrine non-neuroendocrine neoplasm
PFS | OS | |||||||
n | Median (mo) | 95%CI | P value | n | Median (mo) | 95%CI | P value | |
Primary tumour site | ||||||||
Lower GI | 35 | 6.6 | 4.6-7.4 | 0.008 | 37 | 9.6 | 5.21-15.2 | < 0.001 |
PB | 7 | 4.4 | 0.8-NR | 7 | 4.4 | 2-NR | ||
Upper GI | 11 | 9.5 | 5.1-NR | 11 | 9.5 | 5.1-NR | ||
Unknown | 1 | 1.3 | - | 1 | 1.3 | - | ||
Age at diagnosis | ||||||||
< 70 yr | 32 | 5.9 | 4.3-9.5 | 0.19 | 32 | 9.5 | 5.2-16.3 | 0.23 |
≥ 70 yr | 22 | 5.6 | 3.8-8.0 | 22 | 9.0 | 4.6-14.7 | ||
ECOG PS | ||||||||
0-1 | 36 | 6.9 | 4.6-8.2 | 0.9 | 36 | 9.6 | 5.216.3 | 0.45 |
≥ 2 | 13 | 5.9 | 3.4-NR | 13 | 5.9 | 4.6-NR | ||
Gender | ||||||||
Female | 20 | 5.2 | 2.6-9.1 | 0.5 | 20 | 7.9 | 3.7-19.8 | 0.96 |
Male | 34 | 6.9 | 4.6-9.5 | 34 | 9.0 | 5.2-15.2 | ||
Predominant component | ||||||||
ADC | 11 | 4.4 | 2.6-NR | 0.08 | 11 | 4.4 | 2.6-NR | 0.14 |
EQUAL | 6 | 9.5 | 4.4-NR | 6 | 34.2 | 12.4-NR | ||
NE | 23 | 5.6 | 4.3-7.2 | 23 | 7.2 | 5.2-13.7 | ||
Grading NE component | ||||||||
G1 | 0 | 0 | ||||||
G2 | 5 | 6.9 | 5.2-NR | 0.65 | 5 | 53.8 | 5.2-NR | 0.34 |
G3 | 49 | 5.6 | 4.4-7.4 | 49 | 9.0 | 5.2-13.4 | ||
Ki-67 of NE component | ||||||||
< 55% | 14 | 7.0 | 5.3-12.9 | 0.78 | 10.7 | 5.6-NR | 0.6 | |
≥ 55% | 32 | 4.7 | 3.9-8.0 | 7.2 | 5.15-13.4 | |||
First line active treatment | ||||||||
No | 13 | 2.2 | 1.6 | < 0.001 | 3.7 | 2.0 | < 0.001 | |
Yes | 40 | 7.1 | 5.2-9.8 | 13.4 | 9.0-16.3 |
- Citation: Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol 2019; 25(39): 5991-6005
- URL: https://www.wjgnet.com/1007-9327/full/v25/i39/5991.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i39.5991