Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

Figure 3 Receiver operating characteristic curves for the concentration of 6-thioguanine nucleotide with the threshold parameters and nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes. The area under the receiver operating characteristic curve for the obtained predicted probabilities based on nucleotide concentrations in different nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes and the level of 6-thioguanine nucleotide was 0.79 (95%CI: 0.76-0.92). 6TGN: 6-thioguanine nucleotide; NUDT15: Nucleoside diphosphate-linked moiety X-type motif 15.