Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

Figure 1 6-thioguanine nucleotide level and its ratio to thiopurine dose according to nucleoside diphosphate-linked moiety X-type motif 15 R139C diplotype. A: The level of 6-thioguanine nucleotide (6TGN) was much higher in the nucleoside diphosphate-linked moiety X-type motif 15 CC group than in the CT and TT groups [^bP < 0.01, 312.4 pmol/8 × 10⁸ red blood cells (RBC) vs 312.4 pmol/8 × 10⁸ RBC vs 135.8 pmol/8 × 10⁸ RBC]. B: There was no difference in the ratio of the level of 6TGN to the thiopurine dose among these three groups. 6TGN: 6-thioguanine nucleotide; RBC: Red blood cells.