Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

Figure 4 Mechanistic role of Wnt1-inducible signaling pathway protein 1 in gastric cancer cells. A and B: Silencing of Wnt1-inducible signaling pathway protein 1 (WISP1) has effects on cell viability of MKN45 and AGS cells; C: Silencing of WISP1 results in a significant decrease in the IC50 value; D and E: Silencing of WISP1 results in γH2AX overexpression and XRCC1 downregulation in MKN45 and AGS cells. NC: The matching scramble control siRNAs were transfected into cell lines as normal controls; RNAi: The siRNAs were transfected into cell lines as RNA interference; WISP1: Wnt1-inducible signaling pathway protein 1.