lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis

Figure 4 HDAC2 regulated hepatocellular carcinoma progression through mediating SNHG15/miR-490-3p. A: HDAC2 expression in HuH-1 cells containing HDAC2 siRNA, si-HDAC2 + miR-490-3p inhibitor or si-HDAC2 + SNHG15 vector; B: HDAC2 expression in HuH-1 cells containing HDAC2 siRNA, si-HDAC2 + miR-490-3p inhibitor or si-HDAC2 + SNHG15 vector; C: Cell proliferation in HuH-1 cells containing HDAC2 siRNA, si-HDAC2 + miR-490-3p inhibitor or si-HDAC2 + SNHG15 vector; D: Cell migration in HuH-1 cells containing HDAC2 siRNA, si-HDAC2 + miR-490-3p inhibitor or si-HDAC2 + SNHG15 vector; E: Cell invasion in HuH-1 cells containing HDAC2 siRNA, si-HDAC2 + miR-490-3p inhibitor or si-HDAC2 + SNHG15 vector. Untreated cells were set as control (NC). ^bP < 0.01. SNHG15: Small nucleolar RNA host gene 15; miR-490-3p: Hsa-miR-490-3p; HDAC2: Histone deacetylase 2; HuH-1: Human hepatoma cell line; siRNA: Small interfering RNA; si-HDAC2: HDAC2 siRNA.