lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis

Figure 2 Direct interaction of lncRNA-SNHG15 and miR-490-3p. A: The binding sites between lncRNA-SNHG15 with miR-490-3p; B: Luciferase reporter assay; C: miR-490-3p expression in 33 randomly selected HCC tissues and normal tissues; D: SNHG15 had negative correlation with miR-490-3p expression in 33 randomly selected HCC tissues; E: miR-490-3p expression regulated by SNHG15 siRNA or vector in HuH-1 cells; F: SNHG15 expression in HuH-1 cells containing miR-490-3p mimics or inhibitor; G: miR-490-3p expression in cells with miR-490-3p mimics or miR-490-3p mimics + SNHG15 vector. H: Cell proliferation in HuH-1 cells containing miR-490-3p mimics or miR-490-3p mimics + SNHG15 vector; I: Cell migration in HuH-1 cells containing miR-490-3p mimics or miR-490-3p mimics + SNHG15 vector; J: Cell invasion in HuH-1 cells containing miR-490-3p mimics or miR-490-3p mimics + SNHG15 vector. Untreated cells were used as control (NC). ^bP < 0.01. SNHG15: Small nucleolar RNA host gene 15; miR-490-3p: Hsa-miR-490-3p; HCC: Hepatocellular carcinoma; siRNA: Small interfering RNA; HuH-1: Hepatocellular carcinoma cell line.