Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil

Table 2 Quality of life according to type of inflammatory bowel disease and disease activity

	CD				UC
	Total	Moderate to severe activity	No or mild activity	P value	Total	Moderate to severe activity	No or mild activity	P value
n	263	118	145		143	36	107
Missing value1	1	0	1		0	0	0
SF-36 scores
Physical component	46.6 [20.6-68.6]	44.0 [20.6-62.3]	48.6 [27.1-68.6]	< 0.001	44.7 [23.4-63.8]	40.5 [23.4-58.8]	46.2 [23.9-63.8]	0.007
Physical functioning	75.0 [10.0-100.0]	70.0 [10.0-100.0]	85.0 [15.0-100.0]	< 0.001	70.0 [0.0-100.0]	55.0 [0.0-100.0]	77.5 [0.0-100.0]	0.043
Physical role	68.8 [0.0-100.0]	50.0 [0.0-100.0]	75.0 [0.0-100.0]	< 0.001	59.4 [0.0-100.0]	40.6 [0.0-100.0]	75.0 [0.0-100.0]	< 0.001
Body pain	52.0 [0.0-100.0]	51.0 [0.0-100.0]	62.0 [10.0-100.0]	< 0.001	51.0 [0.0-100.0]	31.0 [0.0-100.0]	60.5 [0.0-100.0]	0.001
General health	52.0 [0.0-100.0]	46.0 [0.0-100.0]	57.0 [10.0-100.0]	< 0.001	51.0 [5.0-100.0]	31.0 [5.0-100.0]	55.0 [5.0-100.0]	< 0.001
Mental component	45.2 [5.8-67.2]	42.3 [14.0-63.6]	48.4 [5.8-67.2]	0.022	44.2 [7.9-65.0]	35.0 [7.9-64.1]	46.6 [7.9-65.0]	< 0.001
Vitality	56.3 [0.0-100.0]	50.0 [6.3-100.0]	56.3 [0.0-100.0]	0.074	50.0 [0.0-100.0]	37.5 [0.0-93.8]	56.3 [0.0-100.0]	0.002
Social role functioning	62.5 [0.0-100.0]	50.0 [0.0-100.0]	75.0 [0.0-100.0]	0.002	62.5 [0.0-100.0]	50.0 [0.0-100.0]	62.5 [0.0-100.0]	0.002
Emotional role	75.0 [0.0-100.0]	66.7 [0.0-100.0]	79.2 [0.0-100.0]	0.012	75.0 [0.0-100.0]	45.8 [0.0-100.0]	75.0 [0.0-100.0]	0.002
Mental health	65.0 [0.0-100.0]	55.0 [0.0-100.0]	72.5 [0.0-100.0]	0.008	60.0 [0.0-100.0]	45.0 [5.0-100.0]	70.0 [0.0-100.0]	< 0.001
EQ-VAS (cm)	80.0 [5.0-100.0]	70.0 [5.0-100.0]	80.0 [15.0-100.0]	0.003	70.0 [0.0-100.0]	50.0 [0.0-100.0]	80.0 [0.0-100.0]	< 0.001
EQ-5D [no problems], n (%)
Mobility	193 (73.4)	80 (67.8)	113 (77.9)	0.0802	85 (59.9)	17 (47.2)	68 (64.2)	0.0732
Self-care	225 (85.6)	95 (80.5)	130 (89.7)	0.0522	120 (84.5)	29 (80.6)	91 (85.8)	0.4482
Usual activities	125 (47.5)	47 (39.8)	78 (53.8)	0.1582	66 (46.8)	10 (27.8)	56 (53.3)	0.0092
Pain/disco-mfort	87 (33.1)	31 (26.3)	56 (38.6)	0.0362	30 (21.3)	3 (8.3)	27 (25.7)	0.0122
Anxiety/de-pression	95 (36.1)	31 (26.3)	64 (44.1)	0.0392	51 (36.2)	9 (25.0)	42 (40.0)	0.1142
IBDQ score	164.0 [50.0-224.0]	153.5 [50.0-222.0]	178.0 [57.0-224.0]	< 0.001	165.0 [47.0-224.0]	106.0 [48.0-217.0]	178.5 [47.0-224.0]	< 0.001
Bowel symptoms	5.7 [1.4-7.0]	5.3 [1.4-7.0]	6.0 [1.8-7.0]	< 0.001	5.4 [1.3-7.0]	3.7 [1.3-7.0]	6.1 [1.5-7.0]	< 0.001
Emotional health	4.8 [1.2-7.0]	4.4 [1.2-6.9]	5.3 [1.5-7.0]	0.001	4.9 [1.0-7.0]	2.9 [1.2-6.6]	5.3 [1.0-7.0]	< 0.001
Systemic symptoms	4.8 [1.0-7.0]	4.4 [1.2-7.0]	5.0 [1.0-7.0]	< 0.001	4.8 [1.0-7.0]	3.2 [1.0-7.0]	5.2 [1.0-7.0]	< 0.001
Social function	5.4 [1.2-7.0]	5.0 [1.2-7.0]	5.8 [1.4-7.0]	< 0.001	5.4 [1.2-7.0]	3.8 [1.2-7.0]	6.0 [1.2-7.0]	< 0.001
WPAI scores
% TWPI	20.0 [0.0-100.0]	30.0 [0.0-100.0]	19.7 [0.0-100.0]	0.053	5.0 [0.0-100.0]	34.8 [0.0-100.0]	0.0 [0.0-100.0]	0.082
% work time missed	0.0 [0.0-100.0]	4.7 [0.0-100.0]	0.0 [0.0-64.0]	0.009	0.0 [0.0-100.0]	5.9 [0.0-100.0]	0.0 [0.0-100.0]	0.287
% impairment while working	10.0 [0.0-100.0]	10.0 [0.0-80.0]	10.0 [0.0-100.0]	0.336	0.0 [0.0-80.0]	20.0 [0.0-80.0]	0.0 [0.0-80.0]	0.08
% TAI	30.0 [0.0-100.0]	50.0 [0.0-100.0]	20.0 [0.0-100.0]	< 0.001	30.0 [0.0-100.0]	75.0 [0.0-100.0]	10.0 [0.0-100.0]	< 0.001

¹The missing data is due to a patient who has not completed SF-36 at Day 1. All p-values from Mann-Whitney U test, except

²Chi-square test. Data are shown as median [range], except otherwise mentioned. CD: Crohn’s disease; UC: Ulcerative colitis. SF-36: Short-form 36; EQ-5D: Euro quality of life – 5 dimensions; EQ-VAS: EQ-5D visual analog scale. IBDQ: Inflammatory bowel disease questionnaire. WPAI: Work Productivity and Activity Impairment Questionnaire. TWPI: Total work productivity impairment; TAI: Total activity impairment.