Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele

Table 4 Logistic regression analysis of variables associated with spontaneous hepatitis C virus clearance

Variable	Univariate			Multivariate
	OR	95%CI	P value	OR	95%CI	P value
AST, IU/L	1.058	1.040-1.076	< 0.001
ALT, IU/L	1.04	1.026-1.054	< 0.001	1.037	1.019-1.056	< 0.001
LDL-c, mg/dL	0.981	0.973-0.988	< 0.001	0.977	0.963-0.992	0.002
Total cholesterol, mg/dL	0.983	0.977-0.989	< 0.001
Triglycerides, mg/dL	0.993	0.989-0.996	< 0.001	0.992	0.986-0.999	0.027
VLDL-c, mg/dL	0.97	0.953-0.987	0.001
Age, (yr)	1.024	1.003-1.045	0.023
BMI, kg/m2	0.962	0.913-1.013	0.138	0.874	0.790-0.966	0.008
Female, sex	1.358	0.833-2.213	0.22
HDL-c, mg/dL	0.994	0.977-1.011	0.481

Hosmer and Lemeshow test: Chi-square = 4.53, P = 0.806. Only significant variables (P < 0.2) in the univariate analysis were introduced in the multivariate analysis when P < 0.05 was significant. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDL-c: Low-density lipoprotein cholesterol; VLDL-c: Very low-density lipoprotein cholesterol; BMI: Body mass index; HDL-c: High density-lipoprotein cholesterol; OR: Odds ratio; CI: Confidence interval.