Role of ion channels in gastrointestinal cancer

Table 5 Zinc transporters

Gene name	Cancer	Role	Functional activity
ZnT1/SLC30A1	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZnT2/SLC30A2	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZnT3/SLC30A3	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZnT4/SLC30A4	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZnT5/SLC30A5	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
ZnT6/SLC30A6	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
ZnT7/SLC30A7	Esophageal colorectal	Oncogene oncogene	Increased mRNA expression in tumors[308,335] Increased mRNA expression in tumors[337]
ZnT8/SLC30A8	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZnT9/SLC30A9	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZIP1/SLC39A1	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Down regulated mRNA expression in tumors[313]
ZIP2/SLC39A2	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	mRNA expression down-regulated in tumors[313]
ZIP3/SLC39A3	Pancreatic	Tumor suppressor	Decreased expression in adenocarcinoma[308,313,331,343]
		Oncogene	Medium to high mRNA expression in multiple human PC cell lines[313]
ZIP4/SLC39A4	Hepatocellular	Oncogene	Increased mRNA and protein expression, repressed apoptosis, enhanced cell cycle and migration[308,325,344-346]
	Pancreatic	Oncogene	Increased expression in PDAC and PC cell lines, link to CREB-miR-373 axis, promotes cancer xenograft growth in nude mice[313,325-327]
	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
ZIP5/SLC39A5	Esophageal	Oncogene	Increased expression in ESCC, knockdown in cell lines inhibited migration and invasion[308,334]
	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZIP6/LIV-1/SLC39A6	Pancreatic	Oncogene	Increased expression in tumors and cell lines[313,330]
		Tumor suppressor	Decreased mRNA expression in tumors[313]
	Hepatocellular	Oncogene	Increased mRNA and protein expression[308,347]
	Esophageal	Oncogene	Increased expression in ESCC[308,333]
	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
ZIP7/SLC39A7	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
	Colorectal	Oncogene	Increased mRNA expression in tumors and CRC cell lines, knockdown inhibits cell growth and induces apoptosis in cell lines[339]
	Gastric	Undetermined	Increased mRNA expression, but better patient prognosis[338]
ZIP8/SLC39A8	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
ZIP9/SLC39A9	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
ZIP10/SLC39A10	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
ZIP11/SLC39A11	Colorectal	Oncogene	Increased mRNA expression in tumors[337]
	Gastric	Undetermined	Increased mRNA expression in tumors, better patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
ZIP12/SLC39A12	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
ZIP13/SLC39A13	Gastric	Oncogene	Increased mRNA expression in tumors, worse patient prognosis[338]
	Pancreatic	Tumor suppressor	Decreased mRNA expression in tumors[313]
		Oncogene	Medium to high mRNA expression in multiple human cell lines[313]
ZIP14/SLC39A14	Hepatocellular	Tumor suppressor	Decreased expression in hepatoma tissues[308,348]
	Gastric	Undetermined	Increased mRNA expression in tumors, but better patient prognosis[338]
		Tumor suppressor	Decreased mRNA expression in tumors[313]
	Pancreatic	Oncogene	Medium to high mRNA expression in multiple human cell lines[313]

PDAC: Pancreatic ductal adenocarcinoma; ESCC: Esophageal squamous cell carcinoma; CRC: Colorectal cancer; PC: Pancreatic cancer.