Copyright
©The Author(s) 2019.
World J Gastroenterol. Oct 14, 2019; 25(38): 5732-5772
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5732
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5732
Table 4 Sodium channels
| Gene name (s) | Cancer | Role | Functional activity |
| SCN1A/Nav1.1 | Colorectal | Oncogene | Time to reoccurrence of stage II and III CRC is shorter in patients carrying Nav1.1 variants[302] |
| SCN5A/Nav1.5 | Colorectal | Oncogene | Expression up-regulated; mediates invasion via MAPK signaling; key regulator of a transcriptional network that includes Wnt/β-catenin signaling; associated with poor patient prognosis; linked to upregulation of ER-β[5,294-296] |
| SCN8A/Nav1.6 | Colorectal | Tumor suppressor | Expression down-regulated in CRC tumor tissues compared with control[303] |
| SCN9A/Nav1.7 | Gastric | Oncogene | Expression up-regulated; mechanistically related to upregulation of MACC1 and NHE1[297] |
- Citation: Anderson KJ, Cormier RT, Scott PM. Role of ion channels in gastrointestinal cancer. World J Gastroenterol 2019; 25(38): 5732-5772
- URL: https://www.wjgnet.com/1007-9327/full/v25/i38/5732.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i38.5732