Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer

Figure 6 ADAM28 is closely related to drug resistance-related signaling pathways. A: Enrichment analysis of ADAM28 and its co-expression network in pancreatic cancer; B: GSEA analysis showed that ADAM28 was closely associated with drug metabolism; C: Correlations of ADAM28 with GSTP1, ABCC1, GSTM4, and BCL2 evaluated by the Spearman method. GSEA: Gene set enrichment analysis. ADAM28: AMAM metallopeptidase domain 28; NES: Normalized enrichment score; GSTP1: Glutathione S-transferase pi 1; ABCC1: ATP binding cassette subfamily C member 1; GSTM4: Glutathione S-transferase mu 4; TPM: Transcripts per million.