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©The Author(s) 2019.
World J Gastroenterol. Oct 7, 2019; 25(37): 5702-5710
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5702
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5702
First author, Year | Study design | Study sample (n) | Country | Diagnosis of IBS | Method of H. pylori detection | Odds ratio (95%CI) | Conclusions |
Abdelrazak et al[10], 2015 | Case control | 550 | Egypt | Rome III criteria | Stool antigen test or 13C-urea breath test positive | 8.56 (4.06, 18.05) | Significantly higher rate of H. pylori detection in pediatric patients with IBS compared to healthy controls |
Agreus et al[13], 1995 | Case control | 150 | Sweden | More than 2 of the following symptoms (feeling of incomplete defecation, mucous stools, abdominal distension, abdominal pain or discomfort on defecation or relieved by defecation) and diarrhoea/constipation/or alternating diarrhoea and constipation and abdominal discomfort | Serum IgG by ELISA | 0.56 (0.25, 1.25) | No association between H. pylori seropositivity and dyspepsia or IBS |
Corsetti et al[14], 2004 | Case control | 309 | Belgium | Rome II criteria | Gastric biopsy specimens | 0.74 (0.36, 1.51) | The prevalence of H. pylori infection did not differ between patients with functional dyspepsia alone and patients with functional dyspepsia and IBS |
El-Badry et al[15], 2018 | Cross sectional | 115 | Egypt | Rome III criteria | H. pylori stool coproantigen | NA | H. pylori was detected in 55.7% of patients with IBS |
Gerards et al[16], 2001 | Case control | 46 | Germany | Not specified | 13C-urea breath test | 0.96 (0.24, 3.87) | Rectal distension produced abdominal pain only in patients with IBS and who were H. pylori infected. H. pylori may contribute to visceral hypersensitivity |
Hasan et al[17], 2017 | Cross sectional | 184 | Iraq | Based on clinical and ultrasonography results | Serum IgG by ELISA | 0.54 (0.278, 1.03) | Rate of H. pylori infection similar between patients with IBS and healthy controls |
Locke et al[18], 2000 | Cross sectional | 148 | United States | Abdominal pain with at least two of six Manning criteria symptoms | Serum IgG by ELISA and CagA IgG | 7.22 (2.91, 17.9) | After adjusting for age, CagA-positivity but not H. pylori seropositivity was associated with IBS |
Malinen et al[12], 2005 | Case control | 49 | Finland | Rome II criteria | Real-time PCR analysis of fecal samples | NA | H. pylori was not detected in any of the control or test subjects. PCR assay may lack sensitivity |
McDonald et al[19], 2017 | Cross sectional | 112 | Peru | Rome III criteria | Endoscopy specimens | NA | H. pylori infection was detected in 58 (57.4%) of patients with IBS |
Su et al[20], 2000 | Cross sectional | 69 | Taiwan | Rome I criteria | 13C-urea breath test and endoscopy specimens | NA | H. pylori infection was detected in 33 (47.8%) of patients with IBS |
Xiong et al[21], 2016 | Case control | 502 | China | Rome III criteria | Not specified (presumably seropositivity) | 0.96 (0.77, 1.19) | The prevalence of H. pylori infection in patients with IBS-D was similar to the general population and eradication therapy did not improve symptoms |
Yakoob et al[22], 2012 | Case control | 330 | Pakistan | Rome III criteria | Gastric biopsy specimens | 1.76 (1.12, 2.75) | H. pylori infection was common in patients with IBS-D, and was associated with predominantly cagAs1-positive strains |
Yang et al[11], 2017 | Case control | 670 | China | Rome III criteria | Positive for rapid urease test and 14C-urea breath test | 1.62 (1.19, 2.20) | The rate of H. pylori infection was significantly higher in patients with IBS-D than healthy controls, however, eradication of H. pylori did not improve symptoms |
- Citation: Ng QX, Foo NX, Loke W, Koh YQ, Seah VJM, Soh AYS, Yeo WS. Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis. World J Gastroenterol 2019; 25(37): 5702-5710
- URL: https://www.wjgnet.com/1007-9327/full/v25/i37/5702.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i37.5702