Meta-Analysis
Copyright ©The Author(s) 2019.
World J Gastroenterol. Oct 7, 2019; 25(37): 5702-5710
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5702
Table 1 Characteristics of all studies included in this meta-analysis (arranged alphabetically by first author’s last name)
First author, YearStudy designStudy sample (n)CountryDiagnosis of IBSMethod of H. pylori detectionOdds ratio (95%CI)Conclusions
Abdelrazak et al[10], 2015Case control550EgyptRome III criteriaStool antigen test or 13C-urea breath test positive8.56 (4.06, 18.05)Significantly higher rate of H. pylori detection in pediatric patients with IBS compared to healthy controls
Agreus et al[13], 1995Case control150SwedenMore than 2 of the following symptoms (feeling of incomplete defecation, mucous stools, abdominal distension, abdominal pain or discomfort on defecation or relieved by defecation) and diarrhoea/constipation/or alternating diarrhoea and constipation and abdominal discomfortSerum IgG by ELISA0.56 (0.25, 1.25)No association between H. pylori seropositivity and dyspepsia or IBS
Corsetti et al[14], 2004Case control309BelgiumRome II criteriaGastric biopsy specimens0.74 (0.36, 1.51)The prevalence of H. pylori infection did not differ between patients with functional dyspepsia alone and patients with functional dyspepsia and IBS
El-Badry et al[15], 2018Cross sectional115EgyptRome III criteriaH. pylori stool coproantigenNAH. pylori was detected in 55.7% of patients with IBS
Gerards et al[16], 2001Case control46GermanyNot specified13C-urea breath test0.96 (0.24, 3.87)Rectal distension produced abdominal pain only in patients with IBS and who were H. pylori infected. H. pylori may contribute to visceral hypersensitivity
Hasan et al[17], 2017Cross sectional184IraqBased on clinical and ultrasonography resultsSerum IgG by ELISA0.54 (0.278, 1.03)Rate of H. pylori infection similar between patients with IBS and healthy controls
Locke et al[18], 2000Cross sectional148United StatesAbdominal pain with at least two of six Manning criteria symptomsSerum IgG by ELISA and CagA IgG7.22 (2.91, 17.9)After adjusting for age, CagA-positivity but not H. pylori seropositivity was associated with IBS
Malinen et al[12], 2005Case control49FinlandRome II criteriaReal-time PCR analysis of fecal samplesNAH. pylori was not detected in any of the control or test subjects. PCR assay may lack sensitivity
McDonald et al[19], 2017Cross sectional112PeruRome III criteriaEndoscopy specimensNAH. pylori infection was detected in 58 (57.4%) of patients with IBS
Su et al[20], 2000Cross sectional69TaiwanRome I criteria13C-urea breath test and endoscopy specimensNAH. pylori infection was detected in 33 (47.8%) of patients with IBS
Xiong et al[21], 2016Case control502ChinaRome III criteriaNot specified (presumably seropositivity)0.96 (0.77, 1.19)The prevalence of H. pylori infection in patients with IBS-D was similar to the general population and eradication therapy did not improve symptoms
Yakoob et al[22], 2012Case control330PakistanRome III criteriaGastric biopsy specimens1.76 (1.12, 2.75)H. pylori infection was common in patients with IBS-D, and was associated with predominantly cagAs1-positive strains
Yang et al[11], 2017Case control670ChinaRome III criteriaPositive for rapid urease test and 14C-urea breath test1.62 (1.19, 2.20)The rate of H. pylori infection was significantly higher in patients with IBS-D than healthy controls, however, eradication of H. pylori did not improve symptoms