Evaluation and comparison of short chain fatty acids composition in gut diseases

Table 6 Median ± standard deviation of each short chain fatty acid’ concentration (μmol/g) in patients and healthy controls

SCFA (μmol/g)	HC	CD	CRC	AP	Intergroup comparisons (P value)
					HC/CD	HC/CRC	HC/AP	CD/CRC	CD/AP	CRC/AP
Acetic acid	30.9 ± 14.4	37.6 ± 17.9	15.4 ± 7.2	19.0 ± 17.2	0.254	< 0.001	0.0567	< 0.0001	0.031	0.772
Propionic acid	7.6 ± 4.3	8.3 ± 4.4	5.5 ± 2.9	7.8 ± 7.1	0.615	0.230	0.559	0.116	0.357	0.809
Butyric acid	7.1 ± 5.9	8.0 ± 5.8	6.7 ± 5.2	9.0 ± 12.4	0.401	0.756	0.636	0.502	0.357	0.629
isoButyric acid	0.7 ± 0.3	1.2 ± 0.6	1.4 ± 1.1	0.9 ± 0.9	0.008	0.116	0.889	0.831	0.357	0.187
isoValeric acid	0.5 ± 0.2	0.7 ± 0.6	1.3 ± 1.1	2.0 ± 3.9	0.273	0.032	0.802	0.115	0.590	0.460
Valeric acid	0.9 ± 0.7	1.2 ± 0.7	1.4 ± 1.0	1.1 ± 1.1	0.128	0.151	1.00	0.635	0.522	0.356
Total	47.7 ± 22.9	56.8 ± 27.4	32.5 ± 17.5	39.8 ± 39.3	0.380	0.044	0.187	0.005	0.084	0.846

P values assessed with Wilcoxon test. The intergroup comparisons were assessed using the Wilcoxon test. SCFA: Short chian fatty acid; HC: Healthy control; CD: Celiac disease; AP: Adenomatous polyposis; CRC: Colorectal cancer.