Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma

Table 1 Characteristics of the study population (n = 535)

Characteristic	CHB (n = 359)	HCC (n = 176)	P-value
Age (yr)	49 (39-59)	53 (47-62)	< 0.001
Gender (male: female)	281:78	152:24	0.025
PIVKA-II (mAU/mL)	22.88 (16.00-37.70)	4882.77 (274.98-30000)	< 0.001
AFP (ng/mL)	31.00 (5.30-126.00)	510.05 (25.91-9583.93)	< 0.001
γ-GT (U/L)	92.00 (47.50-160.70)	151.55 (68.10-346.20)	< 0.001
AST (U/L)	138.40 (56.00-367.00)	76.25 (44.25-131.75)	< 0.001
γ-GT/AST	0.58 (0.26-1.22)	1.84 (0.95-3.38)	< 0.001
HBV DNA+, n (%)	258 (71.87%)	88 (50.00%)	NA
Early-stage HCC, n (%)	NA	74 (42.05%)	NA

Data are expressed as the median (interquartile range) or number (%). CHB: Chronic hepatitis B; HCC: Hepatocellular carcinoma; PIVKA-II: Protein induced by vitamin K absence or antagonist II; AFP: Alpha-fetoprotein; γ-GT: Gamma-glutamyltransferase; AST: Aspartate aminotransferase; NA: Not applicable.