LncRNA-ATB promotes autophagy by activating Yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma

Figure 1 LncRNA-ATB is significantly up-regulated in human hepatocellular carcinoma tissues and predicts a poor prognosis. A: Relative expression levels of lncRNA-activated by transforming growth factor beta (lncRNA-ATB) in hepatocellular carcinoma (HCC) tissues and adjacent normal tissues; B: Relative expression levels of lncRNA-ATB in HCC patients with larger tumor sizes (> 5 cm) and smaller tumor sizes (≤ 5 cm); C: Relative expression levels of lncRNA-ATB in HCC patients with early stage (I/II) and advanced stage (III/IV) disease; D: Kaplan-Meier analysis of overall survival in 72 HCC patients according to median lncRNA-ATB expression. The log-rank test was used to calculate the P-value. Data are expressed as the mean ± SD of three independent experiments. Statistical significance is indicated at ^aP < 0.05. HCC: Hepatocellular carcinoma; LncRNA-ATB: LncRNA-activated by transforming growth factor beta.