Autoimmune hepatitis in human immunodeficiency virus-infected patients: A case series and review of the literature

Table 2 Baseline characteristics of 13 human immunodeficiency virus-infected patients at the time of autoimmune hepatitis diagnosis

Case	Sex	Age	HIV status				Presentation, duration (mo)	Lab values1									AIH score
			Duration (yr)	Current ART regimen, duration (year or month)	Viral load, duration (year or month)	CD4+ count in 2 and 1 years ago and at AIH presentation		AST	ALT	ALP	TB	Albumin	Globulin	ANA titer	ASMA	IgG
1	M	47	7	TDF/FTC/EFV, 4 yr	< 40, 3 yr	761, 885, 963	Rising ALT, 10 mo	121	263	145	0.8	4.4	4.8	1:80	+	2930	7
2	M	44	21	TDF/FTC/EFV, 1 yr	< 40, 5 yr	588, 669, 798	Rising ALT, 2 mo	130	172	172	0.4	4.5	4	1:80	-	1310	5
3	M	61	10	TDF/FTC/EFV, 8 yr	< 40, 6 yr	496, -, 646	Rising ALT, 31 mo	168	177	189	0.8	4.0	4.8	> 1280	-	1890	6
4	M	26	1	TDF/3TC/EFV, 6 mo	< 40, 1 mo	-, -, 82	Rising ALT, 7 mo	199	197	106	0.8	4.6	4.6	< 1:40	-	1920	5
5	F	30	7	TDF/3TC/EFV, 6 yr	< 40, -	-, -, 772	Rising ALT, 9 mo	236	157	191	0.4	3.6	5.9	> 1:1280	-	4100	7
6	F	29	6	TDF/FTC/EFV, 6 yr	< 40, -	-, -, 731	Rising ALT, 10 mo	108	133	125	1.0	4.1	3.7	1:320	-	1710	5
7	F	57	25	TDF/3TC/EFV, 8 yr	< 40, 7 yr	583, 477, 384	Rising ALT, 24 mo	106	49	357	0.6	3.7	6.5	1:2560	-	2333	7
8	F	40	10	TDF/3TC/EFV, 6 yr	< 40, 5 yr	-, 415, 480	Rising ALT, 4 mo	269	353	237	0.7	4.1	3.9	< 1:40	+	1860	5
9	F	46	6	TDF/FTC/EFV, 3 yr	< 40, -	-, -, 451	Rising ALT, 20 mo	178	230	262	1.4	3.8	4.2	> 1:1280	+	2050	7
10	F	34	2	TDF/FTC/EFV, 1 yr	< 40, 10 mo	-, 377, 557	Rising ALT, 11 mo	191	205	112	1.3	3.8	4.1	1:320	+	2580	7
11	F	31	2	TDF/FTC/EFV, 6 mo	< 40, 1 mo	-, -, 563	Jaundice, 1 mo	393	266	133	6.3	3.1	5.1	1:320	+	3710	7
12	F	40	13	TDF/FTC/EFV, 3 yr	< 40, 3 yr	320, 298, 216	Rising ALT, 6 mo	314	150	304	2.0	3.3	6.8	> 1:2560	-	5050	7
13	M	39	4	ABC/RPV/3TC, 1 yr	< 40, 2 yr	-, 52, 310	Rising ALT, 23 mo	63	124	100	0.7	4.1	4.4	1:80	-	2250	7

¹Unit of labs: AST, ALT, and ALP – U/L, TB and IgG – mg/dL, albumin and globulin – g/dL. 3TC: Lamivudine; ABC: Abacavir; EFV: Efavirenz; RPV: Rilpivirine; TDF: Tenofovir; AIH: Autoimmune hepatitis; HIV: Human immunodeficiency virus.