De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature

Table 1 Incidence of de novo malignancies in adult orthotopic liver transplant patients

				Number and % incidence of de novo malignancy types in all orthotopic liver transplant recipients
Author	Yr	Number of patients	Number of DNM	PTLD	Skin and Kaposi	Head and Neck	Lung	Renal	Colon	Prostate	Breast	Gynecological	Others
Jonas et al[72]	1997	458	33	7 (1.5)	8 (1.7)	2 (0.4)	3 (0.7)	0	0	0	3 (0.7)	7 (1.5)	3 (0.6)
Jain et al[134]	1998	1000	57	NA	24 (2.4)	7 (0.7)	8 (0.8)	2 (0.2)	4 (0.4)	3 (0.3)	3 (0.3)	0	6 (0.6)
Kelly et al[135]	1998	888	31	NA	8 (0.9)	6 (0.7)	1 (0.1)	0	3 (0.3)	0	2 (0.2)	1 (0.1)	10 (1.1)
Jimenez et al[136]	2002	505	62	13 (2.6)	16 (3.2)	10 (2.0)	6 (1.2)	NA	NA	NA	NA	NA	17 (3.3)
Saigal et al[73]	2002	1140	30	NA	14 (1.2)	3 (0.3)	0	3 (0.3)	1 (0.1)	0	2 (0.2)	1 (0.1)	6 (0.5)
Sanchez et al[137]	2002	1421	125	35 (2.5)	42 (3.0)	4 (0.3)	11 (0.8)	3 (0.2)	9 (0.6)	0	7 (0.5)	2 (0.1)	13 (0.8)
Benlloch et al[17]	2004	772	41	10 (1.3)	NA	9 (1.2)	8 (1.0)	3 (0.4)	2 (0.3)	1 (0.1)	2 (0.3)	2 (0.3)	4 (0.5)
Oo et al[138]	2005	1778	141	18 (1.0)	51 (2.9)	NA	14 (0.8)	NA	18 (1.0)	NA	11 (0.6)	1 (0.06)	28 (1.6)
Yao et al[12]	2006	1043	53	9 (0.9)	17 (0.6)	3 (0.3)	5 (0.5)	2 (0.2)	6 (0.6)	0	4 (0.4)	2 (0.2)	5 (0.5)
Aberg et al[81]	2008	540	39	9 (1.7)	11 (2.0)	2 (0.3)	NA	2 (0.3)	2 (0.3)	2 (0.3)	1 (0.1)	NA	10 (1.8)
Jiang et al[20]	2008	2034	113	44 (2.1)	NA	3 (0.1)	10 (0.5)	4 (0.2)	14 (0.7)	5 (0.2)	5 (0.2)	NA	24 (1.2)
Baccarani et al[139]	2010	417	43	9 (2.1)	8 (1.9)	8 (1.9)	4 (0.9)	0	2 (0.5)	0	1 (0.2)	3 (0.7)	8 (1.9)
Engels et al[5]	2011	37888	1563	365 (1.0)	NA	NA	300 (0.8)	67 (1.8)	NA	NA	NA	NA	831 (2.2)
Chatrath et al[140]	2013	534	80	16 (3.0)	24 (4.5)	9 (1.7)	13 (2.4)	1 (0.2)	1 (0.2)	1 (0.2)	NA	1 (0.2)	14 (2.6)
Schrem et al[141]	2013	2000	120	23 (1.1)	NA	11 (0.5)	14 (0.7)	7 (0.3)	13 (0.6)	5 (0.2)	8 (0.4)	10 (0.5)	29 (1.4)
Krynitz et al[32]	2013	1221	150	27 (2.2)	58 (4.7)	4 (0.3)	6 (0.5)	2 (0.1)	6 (0.5)	4 (0.3)	7 (0.6)	10 (0.8)	26 (2.1)
Mouchli et al[62]	2017	373	64	22 (5.9)	5 (1.3)	NA	NA	11 (2.9)	11 (2.9)	7 (1.9)	5 (1.3)	3 (0.8)	0
Egeli et al[142]	2017	429	9	NA	1 (0.2)	2 (0.4)	5 (1.1)	NA	NA	NA	NA	NA	1 (0.2)
Taborelli et al[143]	2018	2832	266	37 (1.3)	72 (2.5)	34 (1.2)	28 (1.0)	4 (0.2)	21 (0.7)	2 (0.1)	4 (0.2)	3 (0.1)	65 (2.1)

NA: Not available; DNM: De novo malignancy; PTLD: Post-transplant lymphoproliferative disease.