Liver stiffness and serum markers for excluding high-risk varices in patients who do not meet Baveno VI criteria

Table 5 Performance of liver stiffness measurement and serum markers of liver fibrosis in predicting high-risk varices in patients with alanine aminotransferase or total bilirubin ≥ 2 upper limit of normal

Variable	AUROC (95%CI)	P-value	Cutoffvalue	Se (%)	Sp( %)	PPV (%)	PLR	Spared gastroscopies, n = 91, (%)
LSM	0.672 (0.565-0.766)	0.0508
PLT	0.741 (0.639-0.827)	< 0.0001	100.0	100	51.28	25.5	2.05	40/91 (43.9)
Lok index	0.814 (0.718-0.888)	< 0.0001	0.5596	100	47.44	24.1	1.90	36/91 (39.6)
MELD	0.735 (0.632-0.822)	0.0003	7.0	100	12.82	16.0	1.15	10/91 (11.0)
APRI	0.532 (0.424-0.637)	0.7256
FIB-4	0.576 (0.468-0.679)	0.3329

APRI: Aspartate aminotransferase-to-platelet ratio index; AUROC: Area under the receiver operating characteristic curve; CI: Confidence interval; MELD: Model for End-Stage Liver Disease; PLT: Platelet; PLR: Positive likelihood ratio; PPV: Positive predictive value; Se: Sensitivity; Sp: Specificity. P < 0.05 was statistically significant.