Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals

Table 4 Survival analysis of overall survival

Variable	Univariate analysis		Multivariate analysis
	Median OS	P-value	HR (95%CI)	P-value
Sex		0.095	1.374 (0.664-2.845)	0.392
Male	39
Female	18
Age (yr)		<0.001	3.926 (1.740-8.858)	0.001
<70	47
≥70	8
Radical surgery		<0.001	0.778 (0.338-1.792)	0.555
Yes	39
No	8
Tumor location		0.386	1.592 (0.738-3.434)	0.236
Colon	15
Rectum	35
Gross type		0.037
Ulcerative	18
Protruding	imponderable
Distant metastasis		<0.001	6.356 (2.543-15.889)	<0.001
Yes	13
No	imponderable
Pathologic type		0.033	6.647 (1.759-25.119)	0.005
NEC	25
NET G3	imponderable
Ki67 index		0.893
<55%	39
≥55%	35
EMVI		0.047
Yes	26
No	Imponderable
Perineural invasion		0.944
Yes	26
No	39
Pretreatment bloodLDH level		0.015
Elevated	7
Not elevated	26

OS: Overall survival; CI: Confidence interval; NEC: Neuroendocrine carcinoma; NET: Neuroendocrine tumor; EMVI: Extramural vascular invasion; LDH: Lactic dehydrogenase; HR: Hazard ratio; NET G3: Neuroendocrine tumor G3.