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©The Author(s) 2019.
World J Gastroenterol. Sep 14, 2019; 25(34): 5097-5104
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5097
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5097
Table 1 Main studies exploring very high dose vs standard proton pump inhibitors dose in Helicobacter pylori eradication regimens
Study | PPI comparison | Antibiotic regimen | Very high dose eradication rate (%) | Standard dose eradication rate (%) |
De Francesco et al[16], 2016 | Esomeprazole 20 mg vs 40 mg bid | 14-d triple therapy (CLA+AMO) | 59/72 (81.9) | 54/73 (73.9) |
Gisbert et al[23], 2005 | Esomeprazole 20 mg vs 40 mg bid | 7-d triple therapy (CLA+AMO) | 117/150 (78) | 111/150 (74) |
Anagnostopoulos et al[24], 2004 | Omeprazole 20 mg vs esomeprazole 40mg bid | 7-d triple therapy (CLA+AMO) | 50/52 (96.1) | 37/52 (71.1) |
Sheu et al[25], 2005 | Omeprazole 20 mg vs esomeprazole 40 mg bid | 7-d triple therapy (CLA+AMO) | 86/100 (86) | 79/100 (79) |
Manes et al[26], 2005 | Omeprazole 20 mg vs omeprazole 40 mg bid | 7-d triple therapy (CLA+TNZ) | 132/161 (82) | 135/162 (83.3) |
Choi et al[27], 2007 | Omeprazole 20 mg vs esomeprazole 40 mg bid | 7-d triple therapy (CLA+AMO) | 104/148 (70.3) | 290/428 (67.7) |
Hu et al[28], 2017 | Rabeprazole 10 mg vs 20 mg qid | 14-d dual therapy (AMO) | 71/87 (81.6) | 68/87 (78.1) |
- Citation: Ierardi E, Losurdo G, Fortezza RFL, Principi M, Barone M, Leo AD. Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness. World J Gastroenterol 2019; 25(34): 5097-5104
- URL: https://www.wjgnet.com/1007-9327/full/v25/i34/5097.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i34.5097