Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness

Table 1 Main studies exploring very high dose vs standard proton pump inhibitors dose in Helicobacter pylori eradication regimens

Study	PPI comparison	Antibiotic regimen	Very high dose eradication rate (%)	Standard dose eradication rate (%)
De Francesco et al[16], 2016	Esomeprazole 20 mg vs 40 mg bid	14-d triple therapy (CLA+AMO)	59/72 (81.9)	54/73 (73.9)
Gisbert et al[23], 2005	Esomeprazole 20 mg vs 40 mg bid	7-d triple therapy (CLA+AMO)	117/150 (78)	111/150 (74)
Anagnostopoulos et al[24], 2004	Omeprazole 20 mg vs esomeprazole 40mg bid	7-d triple therapy (CLA+AMO)	50/52 (96.1)	37/52 (71.1)
Sheu et al[25], 2005	Omeprazole 20 mg vs esomeprazole 40 mg bid	7-d triple therapy (CLA+AMO)	86/100 (86)	79/100 (79)
Manes et al[26], 2005	Omeprazole 20 mg vs omeprazole 40 mg bid	7-d triple therapy (CLA+TNZ)	132/161 (82)	135/162 (83.3)
Choi et al[27], 2007	Omeprazole 20 mg vs esomeprazole 40 mg bid	7-d triple therapy (CLA+AMO)	104/148 (70.3)	290/428 (67.7)
Hu et al[28], 2017	Rabeprazole 10 mg vs 20 mg qid	14-d dual therapy (AMO)	71/87 (81.6)	68/87 (78.1)

All percentages are expressed as intention to treat. AMO: Amoxicillin; CLA: Clarithromycin; TNZ: Tinidazole; PPI: Proton pump inhibitors.