Copyright
©The Author(s) 2019.
World J Gastroenterol. Sep 14, 2019; 25(34): 5082-5096
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5082
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5082
First author/yr | Setting | High risk condition | Patients included | Modalities of screening | Imaging results | Patients operated on | Operated lesions seen only by the EUS | Histological features with cancer or HGD |
Brentnall et al[37] | Prospective, monocentric | FPC | 14 | EUS | CPis: 10 (77%) Cystic lesio: ? Solid lesio: 6 (46%) | 7 | 1NA | 7 dysplasia |
Rulyak et al[38] | Prospective, monocentric | FPC | 35 | EUS, ERCP | 12 lesions | 12 | ? | 12 dysplasia |
Kimmey et al[78] | Prospective, monocentric | FPC | 46 | EUS, ERCP | CPis: 24 (52%) Cystic lesion: ? Solid lesion: 12 (26%) | ? | ? | ? |
Canto et al[12] | Prospective, monocentric | FPC, PJS, | 38 | EUS first, +/- ERCP, CT, FNA | CPis: 17 (45%) Cystic lesion: ? Solid lesion: 12 (31%) | 7 | 2/7 (1 PC, 1 PanIN3) | 1 PC 1 PanIN3 |
Canto et al[23] | Prospective, monocentric | FPC, PJS, | 78 | EUS, CT +/- ERCP, FNA | CPis: 61 (78%) Cystic lesion: 9 (12%) Solid lesion: 8 (10%) | 7 | 3/7 (1 PanIN 3, 2 PanIN1-2) | 1 PC+IPMN 1 PanIN3 1PanIN3+IPMN |
Poley et al[13] | Prospective, multicentric | FPC, PJS, FAMMM, FBOC, HP, LFS | 44 | EUS | CPis: 3 (7%) Cystic lesion: 7 (16%) Solid lesion: 3 (7%) | 10 | 1NA | 3 PC |
Langer et al[15] | Prospective, multicentric | FPC, FAMMM | 76 | EUS + MRI | CPis: 17 (22%) Cystic lesion: 3 (4%) Solid lesion: 7 (9%) | 7 | 5/7 (9/21 non operated lesions seen only in EUS) | 0 PC or PanIN3 or IPMN with HGD |
Verna et al[33] | Prospective, monocentric | FPC, FBOC | 51 | EUS n = 31 or MRI n = 33 +/- ERCP, FNA | CPis: 9 (29%) Cystic lesion: 12 (39%) Solid lesion: 2 (6%) | 5 | ? (2 solid lesions in EUS and MRI) | 1 PC 1 PanIN2 |
Ludwig et al[34] | Prospective, monocentric | FPC | 109 | MRCP or CT EUS, FNA | 18 lesions | 6 | ? | 1 PC 2 MD IPMN 1 PanIN-3 1 PanIN-2 |
Schneider et al[40] | Prospective, monocentric | FPC, FAMMM | 72 | EUS, MRI | 13 lesions | 9 | ? | 1 PC 1 PanIN-3 |
Zubarik et al[16] | Prospective, monocentric | FPC, PJS, BRCA2 | 27 | CA19-9 +/- EUS (27/546) | 5 lesions | 5 | 1NA | 1 PC |
Canto et al[25] | Prospective, multicentric | FPC, FBOC, PJS | 216 | CT, EUS, MRI/MRCP | CPis: 54 (25%) Cystic lesion: 79 (36%) Solid lesion: 3 (1.4%) | 5 | ? (20/216 non operated lesions seen only in EUS including 3 solid lesion) | 2 MD-IPMN 1 IPMN+PanIN3 |
Al-Sukhni et al[32] | Prospective, monocentric | FPC, BRCA1/2, FAMMM, LKB1 | 252 | MRI, +/- CT, EUS, ERCP | CPis: ? Cystic lesion: 80 (32%) Solid lesion: 3 (1.2%) | 4 | 3 PC | |
Sud et al[14] | Prospective, monocentric | FPC, BRCA1/2, MMR, CDKN2A, LKB1, PRSS1 | 30 | EUS +/- FNA | 3 lesions | 3 | 1NA | 2 PC |
Mocci et al[10] | Prospective, multicentric | FPC, CDKN2A, MMR, PRSS1 | 41 | EUS, CT +/- MRI, FNA | CPis: 15 (37%) Cystic lesion:4 (10%) Solid lesion: 2 (5%) | 1 | 2NA | 1 NET 1 PanIN3 |
Vasen et al[31] | Prospective, multicentric | FPC, CDKN2A, BRCA 1/2 | 411 | MRI, EUS, CT, FNA | CPis: ? Cystic lesion: 138 (34%) Solid lesion: 16 (4%) | 30 | 2/30 (866 MRIs and 106 EUS performed) | 16 PC 3 PanIN3 1 IPMN with high grade |
Bartsch et al[4] | Prospective, multicentric | FPC, BRCA1/2, PALB2 | 234 | MRI, EUS, CT, FNA | CPis: ? Cystic lesion: 125 (49%) Solid lesion: 9 (4%) | 21 6/253 (2%) lesions (2 malignant and HGD) | ? | 2 PC 3 PanIN3 1 IPMN with HGD; multifocal PanIN2±BD-IPMN±AFL 1 NET 8 PanIN-2 |
Harinck et al[27] | Prospective, multicentric | FPC, BRCA1/2, CDKN2A, LKB1, TP53, MMR | 139 | MRI +/- EUS | CPis: 41 (30%) Cystic lesion: 67 (48%) Solid lesion: 2 (1.4%) | 2 | 2/2 (1 PC, 1 PanIN-2) | 1 PC 1 PanIN-2 |
- Citation: Lorenzo D, Rebours V, Maire F, Palazzo M, Gonzalez JM, Vullierme MP, Aubert A, Hammel P, Lévy P, Mestier L. Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer. World J Gastroenterol 2019; 25(34): 5082-5096
- URL: https://www.wjgnet.com/1007-9327/full/v25/i34/5082.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i34.5082