Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer

Table 1 Risk of pancreatic cancer based on genetic mutations

Condition	Gene	Relative risk of PC compared to the general population	Risk of pancreatic cancer at 70 yr (%)	% Among inherited cancers
No family history		1	0.5-1	?
2 first degree relatives with PC	Unknown	5-7	5-12	80-85
3 first degree relatives with PC	Unknown	32	40
Hereditary breast ovarian cancer syndrome	BRCA1	2-4	3-4	1-5
	BRCA2	2-10	4-5	5-20
Genetic pancreatitis	PRSS1	50-80	40-55	1-4
FAMMM	CDKN2A	10-25	5-25	2-3
Peutz-Jeghers syndrome	STK11	100-130	30-40	1-3
Lynch syndrome	MLH1, MSH2, MSH6, PMS2	4-8	3-5	1-3

PC: pancreatic cancer; FAMMM: Familial atypical multiple mole melanoma.