Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

Figure 1 Metabolic parameters in ob/ob mice fed amylin liver non-alcoholic steatohepatitis (AMLN) or Gubra amylin non-alcoholic steatohepatitis (GAN) diet for 8-16 wk. A: Body weight; B: Body composition; C: Terminal liver weight (week 16); D: An intraperitoneal glucose tolerance test (ipGTT) was performed in week 7 of the feeding period, glucose excursion curves; E: Glucose area under the curve (AUC, 0-180 min); F: Plasma insulin (0, 15, 30 min). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs chow-fed C57BL/6J (Chow C57) controls; ^dP < 0.001 vs amylin liver non-alcoholic steatohepatitis (AMLN) diet (n = 5-6 mice per group). AMLN: Amylin liver non-alcoholic steatohepatitis diet; GAN: Gubra amylin non-alcoholic steatohepatitis diet; iPGTT: Intraperitoneal glucose tolerance test.