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©The Author(s) 2019.
World J Gastroenterol. Sep 7, 2019; 25(33): 4985-4998
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4985
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4985
Complete response (n = 199) | Incomplete response (n = 33) | Univariate | Multivariate | |||||
OR | 95%CI | P value | OR | 95%CI | P value | |||
Gender (male) | 130 (65.3%) | 20 (60.6%) | 1.225 | (0.575-2.610) | 0.600 | |||
Age, yr | 47.3 ± 11.9 | 43.6 ± 10.9 | 1.028 | (0.996-1.062) | 0.087 | |||
HBeAg status (positive) | 106 (53.3%) | 30 (90.9%) | 0.114 | (0.034-0.386) | < 0.001 | 0.438 | (0.086-2.226) | 0.320 |
HBV-DNA, log10 IU/mL | 5.97 ± 1.40 | 7.69 ± 1.13 | 0.402 | (0.290-0.559) | < 0.001 | 0.185 | (0.083-0.412) | < 0.001 |
qHBsAg, log10 IU/mL | 3.46 ± 0.57 | 3.89 ± 0.74 | 0.270 | (0.134-0.544) | < 0.001 | 1.492 | (0.501-4.447) | 0.473 |
AST, IU/L | 94.6 ± 69.5 | 83.0 ± 47.2 | 1.003 | (0.997-1.009) | 0.361 | |||
ALT, IU/L | 103.5 ± 92.7 | 91.6 ± 57.5 | 1.002 | (0.997-1.006) | 0.474 | |||
Total bilirubin, mg/dL | 0.95 ± 0.57 | 0.76 ± 0.30 | 2.201 | (0.964-5.024) | 0.061 | |||
Albumin, g/dL | 4.06 ± 0.53 | 4.14 ± 0.44 | 0.743 | (0.351-1.573) | 0.438 | |||
Prothrombin time, INR | 1.05 ± 0.16 | 1.01 ± 0.10 | 8.323 | (0.444-155.931) | 0.156 | |||
Platelet count, × 103/mm3 | 164.6 ± 63.8 | 182.6 ± 53.0 | 0.995 | (0.990-1.001) | 0.128 | |||
Significant fibrosis | 105 (52.8%) | 13 (39.4%) | 1.718 | (0.810-3.644) | 0.158 | |||
Liver cirrhosis | 58 (29.1%) | 6 (18.2%) | 1.851 | (0.726-4.720) | 0.197 | |||
HCC | 33 (16.6%) | 3 (9.1%) | 1.988 | (0.573-6.899) | 0.279 | |||
High genetic barrier | 180 (90.5%) | 12 (36.4%) | 16.579 | (7.069-38.882) | < 0.001 | 82.076 | (14.945-450.760) | < 0.001 |
Pre-existing rtM204I | 9 (4.5%) | 8 (24.2%) | 0.148 | (0.052-0.419) | < 0.001 | 0.014 | (0.002-0.096) | < 0.001 |
- Citation: Choe WH, Kim K, Lee SY, Choi YM, Kwon SY, Kim JH, Kim BJ. Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations. World J Gastroenterol 2019; 25(33): 4985-4998
- URL: https://www.wjgnet.com/1007-9327/full/v25/i33/4985.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i33.4985