Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations

Table 3 Rates of positive detection of hepatitis B virus wild type (YMDD) and rtM204I variant (YIDD) in 410 samples by LNA real-time PCR

Type of detection	No. of samples	Percentage
Clinical samples	410	100%
Identified	403	98.3%
YIDD	17	4.1%
YIDD exclusively	9	2.2%
YIDD + YMDD	3	0.7%
YIDD + YMDD + YIDD with ATA codon1	1	0.2%
YIDD + YMDD	1	0.5%
YIDD + YMDD	3	0.7%
YMDD	394	96.3%
YMDD exclusively	385	93.9%
YMDD + unknown variant	1	0.2%
Unidentified	7	1.7%
Non-target Tm	2	0.5%
HEX 50.4 °C; YVDD1	1	0.2%
HEX 57.9 °C; YMDD with Y of TAC codon1	1	0.2%
No positive signal	5	1.2%

Bold type indicates dominant form.

¹The variants were identified by direct sequencing of PCR products. T_m: Melting temperature.