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©The Author(s) 2019.
World J Gastroenterol. Aug 21, 2019; 25(31): 4300-4319
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4300
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4300
Figure 1 Schematic representation of the oligomeric states of mammalian MAT enzymes.
MAT1A and MAT2A genes encode the catalytic subunits MATα1 and MATα2, respectively. Both MATα1 and MATα2 can be organized as dimers and tetramers. MAT2B encodes the regulatory subunit for which there are four isoforms, MATβV1, MATβV2, MATβV2a, and MATβV2b with the former two being the major splice variants. MATα2 and MATβ interact to give rise to the MATα2β complexes. The MAT(α2)4(βV1)2 and MAT(α2)4(βV2)2 complexes consist of a MATα2 tetramer flanked by two MATβV1 or MATβV2 subunits.
- Citation: Murray B, Barbier-Torres L, Fan W, Mato JM, Lu SC. Methionine adenosyltransferases in liver cancer. World J Gastroenterol 2019; 25(31): 4300-4319
- URL: https://www.wjgnet.com/1007-9327/full/v25/i31/4300.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i31.4300