Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance

Table 3 Examples of inflammatory mediators produced by different inflammatory cells

Cell type	Inflammatory mediators	Functions	Ref.
M1 macrophage	IL6, TNF, IL12A, IL12B, IL23A, CXCL5, CXCL9, CXCL10, CXCL11,	Activation of inflammation	Murray et al[178]
M2 macrophage	IL10, CCL4, CCL13, CCL17, CCL18, MMP1, TGFB1	Resolution of inflammation	Murray et al[47]
Th1 lymphocyte	IFNG, IL2	Activation of cytotoxic immune response	Zhu et al[55]
Th2 lymphocyte	IL4, IL5, IL10, IL13	Activation of humoral immune response	Zhu et al[55]
Th17 lymphocyte	IL17A, IL17F, IL21, IL22	Activation of neutrophils	Zhu et al[55]
Treg lymphocyte	TGFB	Immunosuppression	Zhu et al[55]
Plasma cell	IL10, IL35. TNF, IL17A, CSF2	Both pro- and anti-inflammatory mediators	Dang et al[156]
Neutrophil	IL1A, IL1B, IL1RA, IL6, IL12 CXCL8, CXCL9, CXCL10, CXCL11, CCL2, CCL3, CCL4, TGFB1, VEGFA	Activation of inflammation; depending on the type of polarization, also anti-inflammatory mediators are secreted	Tecchio et al[58]
Eosinophil	IL1A, IL2, IL4, IL6, IL12, CXCL1, CXCL8, CXCL10, CCL3, CCL5, CCL11	Th2 type immune responses	Davoine et al[185]
Myeloid derived suppressor cell	IL10, TGFB	Immunosuppression	Bronte et al[87]
Mast cell	IL4, IL5, IL6, TNF, CSF2	Th2 type immune responses	Amin et al[186]