Multiple “Omics” data-based biomarker screening for hepatocellular carcinoma diagnosis

doi:10.3748/wjg.v25.i30.4199

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2019; 25(30): 4199-4212
Published online Aug 14, 2019. doi: 10.3748/wjg.v25.i30.4199

Table 2 Phases (I, II, III) of biomarker development and corresponding candidate biomarkers

Phases	Description	Biomarkers	Ref.
Phase I	Preclinical exploratory studies	miRNA	[114]
		Metabolomic	[115]
		Cell-free DNA	[116]
Phase II	Clinical essay and validation	AFP-L3	[9]
		Dickkopf-1	[101]
		DCP(Des-carboxyprothrombin)	[9]
		GPC3 (Glypican-3)	[102]
		Golgi protein-73	[117]
		Squamous cell carcinoma antigen	[118]
		miRNA	[114]
Phase III	Retrospective longitudinal studies	Osteopontin	[99]
		Midkine	[100]
		GALAD score	[85]

AFP-L3: α-fetoprotein-L3 (binding fraction); DCP: Des-γ-carboxyprothrombin; GPC3: Glypican-3.

Citation: Liu XN, Cui DN, Li YF, Liu YH, Liu G, Liu L. Multiple “Omics” data-based biomarker screening for hepatocellular carcinoma diagnosis. World J Gastroenterol 2019; 25(30): 4199-4212
URL: https://www.wjgnet.com/1007-9327/full/v25/i30/4199.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i30.4199