NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production

Figure 1 NKX6. 3 inhibits both cell proliferation and apoptotic cell death in gastric epithelial cells. A: NKX6.3 depletion in HFE-145^shNKX6.3 cells increased both adherent and floating cell populations. Shown are the means ± SEM from three experiments. Superscript letter represents significant difference (^aP < 0.005). B: Caspase 3/7 activity was significantly increased in floating HFE-145^shNKX6.3 cells. Shown are the means ± SEM from three experiments. Superscript letter significant difference (^bP < 0.0001). C: In Western blot analysis, expression of cleaved forms of caspase-3, -9, and poly ADP ribose polymerase (PARP) was increased in floating HFE-145^shNKX6.3 cells.