Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients

Figure 2 The receiver operator characteristic curves of using four blood biomarkers to assess hepatocellular injury severity in 263 chronic hepatitis B patients. The areas under the curves (AUCs) of using serum alanine aminotransferase (ALT, black), bilirubin (yellow), plasma DNA (orange), serum aspartate aminotransferase (green), albumin (purple), and hepatitis B virus DNA (gray) to distinguish between patients with mild-moderate and marked-severe inflammation were 0.8059, 0.7910, 0.7921, 0.6530, 0.4877, and 0.4952, respectively. After the combination of serum ALT, bilirubin, and plasma DNA (blue), there was a statistically significant increase of AUC (0.9564). ALT: Alanine aminotransferase; HBV: Hepatitis B virus; AST: Aspartate aminotransferase; AUC: Area under the curve.