Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats

Figure 6 Effects of berberine on visceromotor response to colorectal distention in rats. We took the average EMG amplitude measured on day 11 subtracted by the average EMG amplitude detected on day 0, and express it as △EMG. A: The amplitude of electromyogram (EMG) was changed in the control group and water avoidance stress (WAS) group under different pressures of colorectal distention (CRD); B: The amplitude of EMG in the control group, WAS group, rifaximin group, 25 mg/kg berberine (BBR) group, and 100 mg/kg BBR group under 60 mmHg of CRD on day 11; C: △EMG of different group rats under different pressures of CRD. Letters a, b, and c: P < 0.05 compared with those in the control group, WAS group, and 25 mg/kg BBR group, respectively. WAS: Water avoidance stress; BBR: Berberine; CRD: Colorectal distention; EMG: Electromyogram.