Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes

Figure 4 Pathology of pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome. A: Acute stage (200 ×). Dilation and congestion of hepatic sinusoidals, the penetration of erythrocytes into the space of Disse; B: Subacute stage (200 ×). Complete loss of pericentral hepatocytes, sinusoidal dilatation.