Acute kidney injury spectrum in patients with chronic liver disease: Where do we stand?

Table 1 Comparison of the definitions of acute-on-chronic liver failure from the Asian Pacific Association for the Study of Liver, American Association for the Study of Liver Diseases-European Association for the Study of the Liver, and World Gastroenterology Organization

Criteria	APSAL	AASLD-EASL	WGO
Preexisting or underlying chronic liver disease	Noncirrhotic chronic liver disease, compensated cirrhosis	Cirrhotic chronic liver disease, cirrhosis with prior decompensation	Noncirrhotic chronic liver disease, compensated cirrhosis, decompensated cirrhosis
Precipitating causes	Alcohol, drugs, hepatotropic viruses, surgery, trauma	Alcohol, drugs, hepatotropic viruses, surgery, trauma, variceal bleeding, infection/sepsis	Alcohol, drugs, hepatotropic viruses, surgery, trauma, variceal bleeding, infection/sepsis
Duration between acute liver injury and ACLF	4 wk	NA	NA
Organ failure	Hepatic failure	Extrahepatic organ failure	Hepatic failure, extrahepatic organ failure

APSAL: Asian Pacific Association for the Study of Liver; AASLD-EASL: American Association for the Study of Liver Diseases-European Association for the Study of the Liver; WGO: World Gastroenterology Organization; NA: Not available.