Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis

doi:10.3748/wjg.v25.i27.3649

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

World J Gastroenterol. Jul 21, 2019; 25(27): 3649-3663
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3649

Table 1 Clinical information and characteristics of included studies

Author (year)	Country	Control	Immuno-therapy interven-tions	Patients		Child-Pugh score A/B/C		Immune cell regimens	Course
Author (year)	Country	Control	Immuno-therapy interven-tions	Control	Trial	Control	Trial	Immune cell regimens	Course
Nakamoto (2007)[19]	Japan	TACE	TACE + DC	11	10	4/7/0	8/2/0	5 × 10⁶	1
Nakamoto (2011)[20]	Japan	TACE	TACE + DC	22	13	NR	5/8/0	5 × 10⁶	1
El Ansary (2013)[21]	Egypt	Supportive treatment	DC	15	15	0/14/1	0/15/0	20 × 10⁶	1
Sun (2015)[22]	China	Resection + FOLFOX6	Resection + DC	80	80	NR	NR	8.9 × 10⁹	6
Lee (2017)[23]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + DC	75	69	NR	NR	3 × 10⁷	6
Weng (2007)[24]	China	TACE + RFA	TACE + RFA + CIK	40	45	33/7/0	36/9/0	1.0-1.5 × 10¹⁰	8/9
Dong (2008)[25]	China	Resection	Resection + CIK	43	84	34/9/0	68/16/0	1.0-2.0 × 10¹⁰	3/5
Hao (2010)[26]	China	TACE	TACE + RFA + CIK	74	72	66/8/0	65/7/0	1.0-5.0 × 10¹⁰	4
Pan (2010)[27]	China	TACE + RFA	TACE + RFA + CIK	39	42	NR	NR	1.0 × 10¹⁰	4
Pan (2013)[28]	China	Resection	Resection + CIK	206	204	206/0/0	204/0/0	1.0-1.5 × 10¹⁰	4
Lee (2015)[29]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + CIK	112	114	112/0/0	114/0/0	NR	16
Pan (2015)[30]	China	Resection	Resection + CIK	520	511	NR	NR	1.0-1.5 × 10¹⁰	4
Chen (2016)[31]	China	Resection	Resection + CIK	118	231	205/12/0	222/9/0	1.0-1.5 × 10¹⁰	4
Li (2016)[32]	China	Oxaliplatin + Capecitabine	CIK	37	37	33(A + B)/4(C)	27(A + B)/10(C)	NR	NR
Chang (2018)[33]	China	Resection	Resection + CIK	145	145	145/0/0	145/0/0	NR	NR
Lee (2018)[34]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + CIK	112	114	112/0/0	114/0/0	6.4 × 10⁹	16
Cui (2014)[35]	China	RFA	RFA + NK/γδT/CIK	32	30	14/18/0	18/12/0	1.2-2.0 × 10⁹	8
Qian (2016)[36]	China	RFA	RFA + NK/γδT/CIK	31	73	NR	NR	1.0-2.0 × 10⁹	8
Qiu (2011)[37]	China	Resection	Resection + DC/CIK	9	9	NR	NR	2.0-20.0 × 10⁹	NR
Niu (2013)[38]	China	Cryoablation	Cytotherapy + DC/CIK	12	21	NR	NR	6.0-10.0 × 10⁹	NR
Shimizu (2014)[39]	Japan	Resection	Resection + DC/CIK	40	35	44/8/0	34/8/0	NR	NR
Yu (2015)[40]	China	Microwave ablation	Microwave ablation + DC/CIK	15	14	15/0/0	13/1/0	NR	NR

TACE: Transcatheter arterial chemoembolization; RFA: Radiofrequency ablation; PEI: Percutaneous ethanol injection; DC: Dendritic cell; CIK: Cytokine-induced killer cell; NK: Nature killer cell; NR: Not reported.

Citation: Cao J, Kong FH, Liu X, Wang XB. Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis. World J Gastroenterol 2019; 25(27): 3649-3663
URL: https://www.wjgnet.com/1007-9327/full/v25/i27/3649.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i27.3649