Quantitative diffusion-weighted magnetic resonance enterography in ileal Crohn's disease: A systematic analysis of intra and interobserver reproducibility

Table 4 Diagnostic performance of apparent diffusion coefficient and signal ratio for differentiating inflammatory lesions from normal terminal ileum

	CD (n = 21)	Normal (n = 23)	P-value	Cut-off value	AUROC	Sensitivity (%)	Specificity (%)
First reader
ADC value	1.52 ± 0.42	2.54 ± 0.49	< 0.001a	1.80	0.923	85.7	95.7
SR value	4.19 ± 1.39	1.44 ± 0.53	< 0.001a	2.24	0.981	90.5	95.7
Second reader
ADC value	1.54 ± 0.46	2.61 ± 0.48	< 0.001a	1.81	0.929	85.7	95.7
SR value	4.22 ± 1.37	1.45 ± 0.53	< 0.001a	2.07	0.988	95.2	95.7

^aP < 0.05 was considered statistically significant. Apparent diffusion coefficient (ADC) and signal ratio parameters are expressed as the mean ± SD, ADC units: ×10^-3 mm²/s. ADC: Apparent diffusion coefficient; SR: Signal ratio; CD: Crohn’s disease; AUROC: Areas under receiver operating characteristic curve.