Colorectal peritoneal metastases: Optimal management review

doi:10.3748/wjg.v25.i27.3484

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2019; 25(27): 3484-3502
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3484

Table 5 Studies on the ClinicalTrials.gov registry investigating the role of pressurized intraperitoneal aerosol chemotherapy

Number Clinical Trial	Experimental therapy	Malignant origin	Cytotoxic drugs	Primary outcomes
NCT03280511 The PIPAC-OPC3 CC Trial	Exploratory Laparoscopy + biopsies + 1^st PIPAC 2 mo after radical primary resection+/-adyuvant chemo + 2^nd PIPAC 5 wk later	High risk colorectal cancer patients	Oxaliplatin (92 mg/m²)	Peritoneal recurrence
NCT03246321 CRC-PIPAC	ePIPAC + leuvocorin + 5-FU iv	Colorectal / appendiceal carcinomas	Oxaliplatin (92 mg/m²)	Major toxicity
NCT03210298	PIPAC/PITAC	Peritoneal metastasis of various origins	Depends on tumor origin	Overall survival
NCT02604784 PI-CaP	PIPAC fixed repeated dose vs PIPAC increasing single dose	Gastric, colorectal and ovarian cancers or primary peritoneal tumors	Cisplatin + doxorubicin or oxaliplatin (92 mg/m²)	Overall response rate

PIPAC: Pressurized intraperitoneal aerosol chemotherapy; ePIPAC: Electrostatic pressurised intraperitoneal aerosol chemotherapy.

Citation: Sánchez-Hidalgo JM, Rodríguez-Ortiz L, Arjona-Sánchez Á, Rufián-Peña S, Casado-Adam Á, Cosano-Álvarez A, Briceño-Delgado J. Colorectal peritoneal metastases: Optimal management review. World J Gastroenterol 2019; 25(27): 3484-3502
URL: https://www.wjgnet.com/1007-9327/full/v25/i27/3484.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i27.3484