Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis

Figure 4 Kaplan-Meier curves for the methylation and methylation-expression of glial cell-derived neurotrophic factor and reelin. A and B: Glial cell-derived neurotrophic factor (GDNF) and reelin (RELN) were ranked by the median of methylation and then scored for each colon cancer patient in accordance with high- or low-level methylation value; C and D: GDNF and RELN were ranked by the median of methylation and expression and then scored for each colon cancer patient in accordance with high- or low-level methylation value and high or low-level expression value. The horizontal axis represents the overall survival time and the vertical axis represents survival function. Hyper-LGs: Hypermethylation and low expression methylation-regulated differentially expressed genes; Hypo-HGs: Hypomethylation and high expression methylation-regulated differentially expressed genes; GDNF: Glial cell-derived neurotrophic factor; RELN: Reelin.