Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells

Figure 4 Effects of raddeanin A on 5-fluorouracil effectiveness in RBE and LIPF155C cell lines. A and B: RBE and LIPF155C cell lines treated with either control or raddeanin A (13 μg/mL) in combination with increasing doses of 5-Fu; C: The half-maximal effective concentration (EC50) and half-maximal lethal concentration values for RBE and LIPF155C cell lines; D and E: The cell colony formation ability in RBE and LIPF155C cell lines. Unique letters shared by the bars suggest significant differences between groups and P < 0.05 was regarded to be statistically significant. 5-Fu: 5-fluorouracil.