Genetic testing vs microforceps biopsy in pancreatic cysts: Systematic review and meta-analysis

doi:10.3748/wjg.v25.i26.3450

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastroenterol. Jul 14, 2019; 25(26): 3450-3467
Published online Jul 14, 2019. doi: 10.3748/wjg.v25.i26.3450

Table 2 Characteristics of studies of microforceps biopsies included in the analysis

Ref.	Type of study	Diagnosis	Sample size	Technical success	Adverse events	Diagnostic yield	Surgical cohort	Mean cyst size and range,(mm)	Cysts < 3 cm	Cyst location	Specific cyst diagnosis	Specific cyst	High risk cysts	Mucinous low risk cysts	Benign cysts	Specific cyst type (MFB/surgical pathology)
Ref.	(study period)		(all patients in the study)	(successful cyst puncture and biopsy)	(major/minor)	(histopathologic diagnosis available)				(H/B/T)	(MFB/all patients)	(MFB/surgical pathology)	(MFB/surgical pathology)	(MFB/surgical pathology)	(MFB/surgical pathology)	IPMN-ADC	IPMN-HG	IPMN-LG	MCN-HG	MCN-LG	SCA	Pseudocyst	NET	Other (ACC)
Mittal et al[18], 2018	Retrospective (Dec 2016-June 2017)	Pathology, cytology and cyst fluid analysis	27	27	0/0	24	4	38 (15-70)	20	14/B+T=13	24/27	2/4	1/1	1/3	0/0	0/0	0/0	1²/3	-	NA	-	-	1/1	-
Zhang et al[20], 2018	Retrospective (Jan 2016- Set 2017)	Pathology, cytology and cyst fluid analysis	48	46	0/0	36	10	31 (12-60)	23	13/22/13	24/48	7/10	3/4	4/5	1/1	1¹/3	1³/0	4/4	-	0¹/1	1/1	-	-	1/1
Basar et al[21], 2018	Retrospective (2015-2016)	Pathology, cytology and cyst fluid analysis	42	38	0/2	26	7	28 (12-60)	24	16/17/9	15/42	6/7	4/4	1/2	1/1	2/2	-	1/1	-	0¹/1	1/1	-	1/1	1/1
Kovacevic et al[19], 2018	Retrospective (Sep 2016-Oct 2017)	Pathology or multidisciplinary conference	31	27	1/2	22	4	34 (12-130)	14	NA/NA/NA	24⁴/31	3/4	0/1	2/2	1/1	0/1	-	3³/2	-	-	-	1/1	-	-
			148	138	1/4	108/148 (73%)	25	33 (12-130)	81		63/148 (42%)	18/25 (72%)	8/10 (80%)	8/12 (67%)	3/3 (100%)	3/6	1/0	8/10	-	0/2	2/2	1/1	2/2	2/2

¹1 nondiagnostic on MFB;

²2 nondiagnostic on MFB;

³1 false negative IPMN associated invasive carcinoma;

⁴2 cases with a suspicion of pseudocyst. MFB: Microforceps biopsy; NA: Non-available data; ND: Nondiagnostic; ACC: Acinar cystadenoma; H/B/T: Head body and tail of the pancreas; ADC: Adenocarcinoma; HG: High-grade; LG: Low-grade; NET: Neuroendocrine tumor.

Citation: Faias S, Pereira L, Luís Â, Chaves P, Cravo M. Genetic testing vs microforceps biopsy in pancreatic cysts: Systematic review and meta-analysis. World J Gastroenterol 2019; 25(26): 3450-3467
URL: https://www.wjgnet.com/1007-9327/full/v25/i26/3450.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i26.3450