Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis

doi:10.3748/wjg.v25.i26.3408

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2019; 25(26): 3408-3425
Published online Jul 14, 2019. doi: 10.3748/wjg.v25.i26.3408

Table 3 Value of selected pathological characteristics in predicting the histological growth patterns of colorectal carcinoma liver metastasis

Pathological characteristic	Value	Group A	Group B
HGP	SE% (CI)	60.0 (35.8-80.2)	85.7 (60.1-97.5)
	SF% (CI)	85.7 (60.1-97.5)	60.0 (35.8-80.2)
	PPV% (CI)	81.8 (52.3-96.8)	66.7 (43.8-83.7)
	NPV% (CI)	66.7 (43.8-83.7)	81.8 (52.3-96.8)
TBS	SE% (CI)	66.7 (41.7-84.8)	71.4 (45,4-88.3)
	SF% (CI)	71.4 (45,4-88.3)	66.7 (41.7-84.8)
	PPV% (CI)	71.4 (45.4-88.3)	66.7 (41.7-84.8)
	NPV% (CI)	66.7 (41.7-84.8)	71.4 (45.4-88.3)
CDR	SE% (CI)	46.7 (24.8-69.9)	92.9 (68.5-99.6)
	SF% (CI)	92.9 (68.5-99.6)	46.7 (24.8-69.9)
	PPV% (CI)	87.5 (52.9-99.4)	61.9 (40.9-79.3)
	NPV% (CI)	61.9 (40.9-79.3)	87.5 (52.9-99.4)
HGP + TBS	SE% (CI)	80.0 (54.8-93.0)	85.7 (60.1-97.5)
	SF% (CI)	71.4 (45.4-88.3)	46.7 (24.8-69.9)
	PPV% (CI)	75.0 (50.5-89.8)	60.0 (38.7-78.1)
	NPV% (CI)	76.9 (49.7-91.8)	77.8 (45.3-96.1)
HGP + CDR	SE% (CI)	80.0 (54.8-93.0)	92.9 (68.5-99.6)
	SF% (CI)	85.7 (60.1-97.5)	26.7 (10.9-52.0)
	PPV% (CI)	85.7 (60.1-97.6)	54.2 (35.1-72.1)
	NPV% (CI)	80.0 (54.8-93.0)	80.0 (37.6-99.0)
TBS + CDR	SE% (CI)	80.0 (54.8-93.0)	92.9 (68.5-99.6)
	SF% (CI)	71.4 (45.4-88.3)	33.3 (15.2-58.3)
	PPV% (CI)	75.0 (50.5-89.8)	56.5 (36.8-74.4)
	NPV% (CI)	76.9 (49.7-91.8)	83.3 (43.7-99.2)
HGP + TBS + CDR	SE% (CI)	86.7 (62.1-97.6)	92.9 (68.5-99.6)
	SF% (CI)	71.4 (45.4-88.3)	20.0 (7.0-45.2)
	PPV% (CI)	76.5 (52.7-90.4)	52.0 (33.5-70.0)
	NPV% (CI)	83.3 (55.2-97.0)	75.0 (30.1-98.7)

HGP: Histological growth pattern; 95%CI: 95% confidence interval; SE: Sensitivity; SF: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; TBS: Tumor budding score; CDA: Crohn’s disease-like appearance.

Citation: Wu JB, Sarmiento AL, Fiset PO, Lazaris A, Metrakos P, Petrillo S, Gao ZH. Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis. World J Gastroenterol 2019; 25(26): 3408-3425
URL: https://www.wjgnet.com/1007-9327/full/v25/i26/3408.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i26.3408