Botulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis

Table 2 Main findings and risk of bias analysis

Effect	No. of studies	Event rate (95%CI)	Heterogeneity (I2)	Significant predictors	Eggers intercept	Fail safe, n
Improvement of obstructive symptoms	14	ER = 0.66 95%CI: 0.55-0.75a	49.5%	None	-0.42	43
Decreasing enterocolitis incidence	3	ER = 0.58, 95%CI: 0.27-0.84b	71.0%	NA	3.27	0
Adverse effects	9	ER = 0.17, 95%CI: 0.10-0.29c	52.1%	NA	-2.78 b	101

^aP = 0.004,

^bP < 0.01,

^cP = 0.001. ER: Event rate; NA: Not applicable; CI: Confidence interval.