Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study

Table 4 Diagnostic performance of magnetic resonance elastography and two-dimensional shear wave elastography, fibrosis index based on four factors score, and aspartate transaminase-to-platelet ratio index for evaluation of significant fibrosis (≥ F2) and cirrhosis (F4)

		AUC (95%CI)	P value	Cutoff	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
MRE	≥ F2	0.906 (0.806, 0.965)	< 0.001	> 2.47 (kPa)	81.8	94.7	97.3	69.2
	F4	0.894 (0.791, 0.958)	< 0.001	> 3.46 (kPa)	88.9	97.8	94.1	95.6
2D-SWE	≥ F2	0.843 (0.730, 0.923)	< 0.001	> 6.73 (kPa)	84.1	68.4	86.0	65.0
	F4	0.816 (0.698, 0.902)	< 0.001	> 9.50 (kPa)	77.8	80.0	60.9	90.0
FIB-4	≥ F2	0.697 (0.568, 0.806)	0.003	> 1.80	70.5	63.2	81.6	48.0
	F4	0.786 (0.665, 0.880)	< 0.001	> 3.22	50.0	97.8	90.0	83.0
APRI	≥ F2	0.717 (0.590, 0.823)	0.001	> 0.49	84.1	52.6	80.4	58.8
	F4	0.701 (0.572, 0.810)	0.006	> 0.96	50.0	84.4	562	80.9

MRE: Magnetic resonance elastography; 2D-SWE: Two-dimensional shear wave elastography; FIB-4: Fibrosis index based on four factors; APRI: Aspartate transaminase-to-platelet ratio index; AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value.