Review
Copyright ©The Author(s) 2019.
World J Gastroenterol. Jul 7, 2019; 25(25): 3151-3167
Published online Jul 7, 2019. doi: 10.3748/wjg.v25.i25.3151
Table 1 Homeobox genes show different roles in the progression of hepatocellular carcinoma
Homeobox genesInvolvement in HCC processTarget genesRef.
HOXA13Colony formation (+), migration (+), Drug resistance (+)[65,67]
HOXA7Proliferation (-)Cyclin e1/cdk2[68]
HOXB7Stemness (+), EMT (+)c-Myc, slug[69]
HMBOX1Autophagy (+), Stemness (-), Immunosuppression (-)PD-L1, Fas[75]
PROX1Drug resistance (+), angiogenesis (+)IL-8, NF-κB, β-catenin[77-79]
NKX3.1Proliferation (-)FOXO1[80]