Development and in vitro study of a bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma

doi:10.3748/wjg.v25.i24.3030

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2019; 25(24): 3030-3043
Published online Jun 28, 2019. doi: 10.3748/wjg.v25.i24.3030

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Figure 3 Hydrodynamic size distribution of antibody-conjugated ultra-small superparamagnetic iron oxides. A: Schematic illustration of the conjugation between antibodies (anti-AFP and anti-GPC3) and USPIO-NHS ester to form single or double antibody-conjugated USPIO probes. B: Hydrodynamic size distribution of USPIO (U), anti-AFP–USPIO (UA), anti-GPC3–USPIO (UG), and anti-AFP–USPIO–anti-GPC3 (UAG). USPIO: Ultra-small superparamagnetic iron oxide; AFP: Alpha-fetoprotein; GPC3: Glypican-3; NHS ester: Succinimidyl ester.

Citation: Ma XH, Wang S, Liu SY, Chen K, Wu ZY, Li DF, Mi YT, Hu LB, Chen ZW, Zhao XM. Development and in vitro study of a bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma. World J Gastroenterol 2019; 25(24): 3030-3043
URL: https://www.wjgnet.com/1007-9327/full/v25/i24/3030.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i24.3030