NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling

doi:10.3748/wjg.v25.i23.2898

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2019; 25(23): 2898-2910
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2898

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Figure 2 Combined NIMA related kinase 2 and ERK expression may predict overall survival in patients with gastric cancer. A: ERK co-expressed with NIMA related kinase 2 (NEK2) in gastric cancer (datasets from TCGA). B: Relative mRNA expression level of ERK analyzed by quantitative real-time PCR in 30 pairs of human gastric cancer tissues. C: ERK expression is significantly correlated to NEK2 expression in human gastric cancer tissues. D: Immunohistochemistry analysis of NEK2 and ERK expression in serial gastric cancer samples. E: Correlation between NEK2 and ERK expression. F: Overall survival of patients with gastric cancer calculated using Kaplan–Meier analysis according to the staining level. NEK2: NIMA related kinase 2.

Citation: Fan WD, Chen T, Liu PJ. NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling. World J Gastroenterol 2019; 25(23): 2898-2910
URL: https://www.wjgnet.com/1007-9327/full/v25/i23/2898.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i23.2898