Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis

Table 2 Diagnostic performance of placental growth factor and Nogo-A for clinically significant, severe portal hypertension and high-risk varicose veins

	Cut-off value1	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	P value
CSPH
PLGF	25 pg/mL	55.7	76.7	84.8	42.6	0.003
Nogo-A	1.12 ng/mL	36.6	93.1	92.9	37.5	0.01
SPH
PlGF	26.8 pg/mL	59.0	79.5	81.8	55.4	0.0001
Nogo-A	1 ng/mL	33.3	92.5	87	48	0.014
High-risk varicose veins
PlGF	19.83 pg/mL	90.5	44.2	30.6	94.4	0.034

¹Cut-off values with most accurate sensitivity and specificity to differentiate patients with the condition from patients without the condition. PlGF: Placental growth factor; SPH: Severe portal hypertension; CSPH: Clinically significant portal hypertension; PPV: Positive predictive value; NPV: Negative predictive value.